Medicinal Chemistry

Description

1      A Brief History of Drug Discovery
2      The Modern Drug Process
3      A Trip through the Body
4      Enzymes as Drug Targets
5      Receptors as Drug Targets
6      Oligonucleotides as Drug Targets
7      Pharmacokinetics
8      Metaboism
9      Molecular Structure and Diversity
10      Lead Discovery
11      Lead Optimization- Traditional Methods
12      Lead Optimization- Hansch Analysis
13      Aspects in Pharmaceutical Synthesis

• Text organization is modeled after medicinal chemistry lectures that are presented at meetings of the American Chemical Society. A typical lecture includes an introduction to a disease, coverage of possible points of intervention for a drug, discovery of weakly active drug hits through screening, selection of drug leads, optimization of a clinical drug candidate, and some details of drug synthesis. These are the central topics of the book and are presented as follows:

• Introduction (3 chapters) — selection of a disease for treatment, FDA approval process
• Pharmacodynamics (3 chapters) — measuring drug activity against enzymes and receptors
• Pharmacokinetics (2 chapters) — drug absorption, distribution, metabolism, and elimination
• Drug Discovery and Synthesis (5 chapters) — hit discovery, lead optimization, drug synthesis

• Carefully selected topics include broader chemical concepts that can be applied to many different drugs as opposed to covering specialized ideas with limited scope and application.

• Each chapter includes the following:

• Learning objectives at the opening of each chapter highlight the key ideas.
• Case Studies in each chapter demonstrate real life applications of newly introduced ideas.
• End-of-chapter summaries provide a synopsis of the chapter’s material.
• Highlighted keywords are collectively listed and defined in the glossary.
• Sample Calculations throughout each chapter demonstrate the use of equations to analyze quantitative data.
• Conceptual end-of-chapter problems test students’ understanding rather than memorization skills

• The appendix features a reference to the top selling orally delivered drugs.

Emphasizing applications of chemistry while reinforcing theory — especially in the areas of organic and physical chemistry — this new text prepares students for career success in the pharmaceutical, medical, and biotech industries. Medicinal Chemistry: The Modern Drug Discovery Process delivers a comprehensive introduction to medicinal chemistry at an appropriate level of detail for a diverse range of undergraduate students (pharmaceutical, chemical engineering, premed, biotechnology). By highlighting the concepts and skills related to drug discovery, Stevens deepens students’ understanding of the knowledge and techniques necessary for their careers. Emphasizing applications of chemistry while reinforcing theory – especially in the areas of organic and physical chemistry – this new text prepares readers for career success in the pharmaceutical, medical, and biotech industries. Medicinal Chemistry: The Modern Drug Discovery Process delivers a comprehensive introduction to medicinal chemistry at an appropriate level of detail for a diverse range of readers. By highlighting the concepts and skills related to drug discovery, Stevens deepens readers’ understanding of the knowledge and techniques necessary for their careers.